• Nebivolol Hydrochloride: Selective β1-Adrenoceptor Inhibi...

  2025-09-22

  This article examines Nebivolol hydrochloride as a highly selective β1-adrenoceptor antagonist, highlighting its application in β1-adrenergic receptor

• Biotin-16-UTP: Expanding Capabilities in RNA-Protein Inte...

  2025-09-19

  Biotin-16-UTP, a biotin-labeled uridine triphosphate analog, empowers advanced in vitro transcription RNA labeling for precise RNA detection, purification, and interaction studies. This article examines its unique applications in RNA-protein interaction studies, with a focus on emerging research in lncRNA biology.

• ARCA EGFP mRNA (5-moUTP): Enhancing Reporter mRNA Reliabi...

  2025-09-18

  Explore the scientific advantages of ARCA EGFP mRNA (5-moUTP) as a direct-detection reporter mRNA for fluorescence-based transfection control in mammalian cells, focusing on stability, innate immune suppression, and translational efficiency.

• Given that there are substitutions between

  2025-03-03

  

  Given that there are 132 substitutions between βAnc and the human β subunit, we wondered whether βAnc could replace the human β subunit in hybrid AChRs formed from ancestral and human subunits. We first confirmed that the β subunit is required for expression of human AChRs in HEK293 2272 by co-trans

• Given that there are substitutions between

  2025-03-03

  

  Given that there are 132 substitutions between βAnc and the human β subunit, we wondered whether βAnc could replace the human β subunit in hybrid AChRs formed from ancestral and human subunits. We first confirmed that the β subunit is required for expression of human AChRs in HEK293 Z-Ligustilide sy

• All scientific data over the years points

  2025-03-03

  

  All scientific data over the years points that 5α-reductase inhibitors undoubtedly are an effective treatment for BPH and associated LUTS, having a favorable risk-benefit profile. In contrast, although some studies indicated positive results, there is still no consensus about their use in BPH or PC

• Earlier studies showed that exposure of cells to

  2025-03-01

  

  Earlier studies showed that exposure of cells to IR caused ATM-dependent phosphorylation of 53BP1, as judged by electrophoretic mobility shift [24], [25], [26]. To date, the only known in vivo 53BP1 phosphorylation site(s) are Ser25 and possibly Ser29 [27]. In the course of our studies, we noticed t

• In previous years evidence emerged that inferred secondary m

  2025-03-01

  

  In previous years, evidence emerged that inferred secondary metabolites in plants might exhibit a potential arginase inhibition [36]. In a recent study, Pham and co-workers showed the inhibitory activity of chlorogenic G-1 (7) and piceatannol (8) (Fig. 3b) on mammalian arginase with IC50s of 10.6 a

• We provide here direct evidences that

  2025-03-01

  

  We provide here direct evidences that AT1 receptors are active in ADSCs since Ang II induces intracellular Ca mobilization in these cells. Data obtained during the observation of Ca influxes led us to the search for the ADSCs subpopulation constantly expressing AT1 receptor. ADSCs are necessary for

• In another study Yerra and Kumar used streptozotocin to indu

  2025-03-01

  

  In another study, Yerra and Kumar (2016) used streptozotocin to induce diabetic neuropathy in rats. Mechanical/thermal hyperalgesia, motor/sensory nerve conduction velocities (MNCV and SNCV) and sciatic nerve blood flow (NBF) were evaluated. In vitro studies of Neuro2a (N2A) cell culture were perfor

• br Acknowledgements This work was supported

  2025-03-01

  

  Acknowledgements This work was supported by Programme Grants from the MRC and the Wellcome Trust (SGC-C and MF). CB was in receipt of a Marie Curie Intra-European Fellowship during part of this work. We thank past and present members of our group for numerous valuable discussions throughout these

• Histochemical analyses using antibody or cDNA probes

  2025-03-01

  

  Histochemical analyses using antibody or cDNA probes reveal the precise cellular location of the 12S-lipoxygenases in tissues of interest. An immunohistochemical study in various rat tissues showed specific expression of the leukocyte-type 12S-lipoxygenase in macrophages in lung and spleen [27]. In

• Similar to Cys Met can undergo ROS mediated oxidation

  2025-03-01

  

  Similar to Cys, Met can undergo ROS-mediated oxidation to Met sulfoxide, which can result in changes in protein conformation and activity [43]. In our results, the Met content in wild ginseng is higher compared to cultivated ginseng (1.3 times, Table 1). Met is a substrate for the synthesis of vario

• Our co IP data show

  2025-03-01

  

  Our co-IP data show that 5HT1A or 5HT2A receptors do not heterodimerize with mGluR1α receptors. Given that both 5-HT and mGlu receptors are GPCRs and produce anxiolytic effects, a degree of cooperativity via a functional cross-talk may still exist between these receptors [11]. In addition to the fun

• In another study authors found

  2025-03-01

  

  In another study, authors found that ADORA1 were present on the intrinsically photosensitive retinal ganglion Fatty acid metabolism inhibitor (ipRGCs), and application of adenosine to rat retinas reduced light-evoked spiking of ipRGCs through suppression of a cAMP-mediated pathway (Sodhi and Hartwi

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