• The exhibited efficacies of bone targeting treatments in pha

  2019-06-11

  

  The exhibited efficacies of bone targeting treatments, in phase III clinical trials, suggest significant progress in delaying skeletal-related events, with improvements having been seen in the direct comparisons between generations of drugs. These findings also lend clear support to the utility of b

• All these receptors tightly control tissue homeostasis and

  2019-06-11

  

  All these receptors tightly control tissue homeostasis, and any dysregulation of these ligand–receptor systems (mutations, overexpression, etc.) disturbs cell communication and leads to pathological situations. Bone formation and bone remodelling are then controlled by a large panel of cytokines and

• br Conclusions br Disclosures br Funding Sources

  2019-06-11

  

  Conclusions Disclosures Funding Sources Introduction Pulmonary vein isolation (PVI) has become an accepted treatment for atrial fibrillation (AF) [1]. The efficacy of PVI is sometimes insufficient, and atrial substrate modification of target specific AF signals indicating the substrate r

• Introduction Pulmonary vein isolation PVI is an

  2019-06-11

  

  Introduction Pulmonary vein isolation (PVI) is an established strategy of paroxysmal atrial fibrillation (PAF) ablation [1–3]. Radiofrequency catheters have been the standard for AF ablation; however, PVI using balloon-based ablation has been increasingly adopted by electrophysiology laboratories a

• energy metabolism Qu dicen las fechas en

  2019-06-11

  

  ¿Qué dicen las fechas en que se ha flexibilizado la posición de ambas partes? Veamos una cita elocuente sobre la situación internacional en la década de los años setenta del siglo pasado, marco en el que se mejoraron las relaciones entre Washington y La Habana, bajo el gobierno de James Carter. Por

• Reframing non communicable diseases NCDs to

  2019-06-11

  

  Reframing non-communicable diseases (NCDs) to “spur a sense of urgency” and “focus attention on effective system-wide interventions” makes sense. With almost three-quarters of NCD deaths now occurring in low-income and middle-income countries (LMICs), the increasing burden of NCDs already has severe

• br Water the main component of Earth

  2019-06-10

  

  Water—the main component of Earth\'s ecosystems—concentrates some of the most worrying global concerns that have emerged during the Anthropocene. When it comes to health considered at a planetary level, the challenges related to water can be sorted into five main categories: pollution, access to w

• br In the cluster randomised controlled trial by Marcel

  2019-06-10

  

  In the cluster randomised controlled trial by Marcel Yotebieng and colleagues (August, 2015) the addition of Step 10 of the UNICEF Baby Friendly Hospital Initiative (BFHI)—that is, the provision of additional support for breastfeeding—did not enhance the effects of steps 1–9, and may even have les

• br Ablation strategies from targeted to homogenization The

  2019-06-10

  

  Ablation strategies – from targeted to homogenization The techniques and principles originally developed in postinfarction scar have been translated and applied to patients with various etiologies of fibrosis and confluent scar including Chagasic cardiomyopathy, nonischemic cardiomyopathy, arrhyt

• The electrophysiological mechanisms underlying high frequenc

  2019-06-10

  

  The electrophysiological mechanisms underlying high frequency activity observed in the PLA during SRAF could be reentry (rotor) or focal discharges (triggered activity). To discriminate between these mechanisms, we perfused ryanodine (10–40μM) or caffeine (5mM) to abolish calcium overload-mediated t

• The so called driver hypothesis has been

  2019-06-10

  

  The so-called driver order KN-93 hydrochloride has been posited in the recent years. Optical mapping studies in isolated sheep hearts have suggested that at least some cases of AF can be maintained by high-frequency reentrant sources (rotors), usually located in the posterior LA, which result in sp

• Introduction The heart beat provides the mechanical force fo

  2019-06-10

  

  Introduction The heart beat provides the mechanical force for the pumping of oxygenated blood to, and deoxygenated blood away from, the peripheral tissues [1]. This depends critically on the orderly activation and recovery of electrical excitation through the myocardium. Disruptions of this can lea

• Brasil ha sido el principal pa s de origen

  2019-06-10

  

  Brasil ha sido el principal país de origen de las importaciones argentinas hasta el punto que en 2011 tales importaciones del vecino sumaron más de 21 000 millones de dólares. Es cierto que la compra de productos brasileños fue disminuyendo desde 2003, que representaba 34% del total de las importaci

• El tenor de aquella declaratoria se

  2019-06-10

  

  El tenor de aquella declaratoria se escribió con estas palabras: De este modo, y al margen de otras consideraciones que pudieran hacerse al respecto, para el caso que nos ocupa es importante significar que la iniciativa mexicana acabó tapiando las puertas de la onu Histone Compound Library la Españ

• br Methods br Discussion We

  2019-06-10

  

  Methods Discussion We observed a significantly lower than expected Day +100 TRM. Other NMAT studies [4,5] have shown similar findings, although 60% of our trial LY2584702 had high risk disease per the CIBMTR classification. In this and other studies, late TRM and disease progression remains p

15632 records 994/1043 page Previous Next First page 上5页 991992993994995 下5页 Last page