• Celiac disease occurs in the small intestine due to

  2020-05-26

  

  Celiac disease occurs in the small intestine due to the ingestion of gluten and triggers an immune response by T-cells resulting in tissue remodelling and malnutrition [6]. Earlier studies by many researchers have shown that the prolamins of gluten are the toxic agent for celiac disease, since they

• Downregulation of tumor suppressors is a major factor

  2020-05-25

  

  Downregulation of tumor suppressors is a major factor that leads to tumorigenesis. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a common tumor suppressor, the ubiquitin e3 ligase of which is often downregulated or even absent in the majority of human cancers, functions as a phosph

• DGK type I http www apexbt

  2020-05-25

  

  DGKη1 (type II DGK) has a separated catalytic domain [10], [13], whereas the domains of DGKα, ε and ζ are not split [1], [2], [3], [4], [5]. Therefore, the structural difference may cause the distinct affinity for DG among these isozymes. Because other type II DGKs (η2, δ1, δ2 and κ) also have the s

• As a basis for the

  2020-05-25

  

  As a basis for the DDR1 substrate identification approach detailed below, we first set out to perform 2D-gel electrophoresis with lysates isolated from collagen-stimulated human breast cancer MDA-MB-231 Phosphoramidon Disodium Salt overexpressing DDR1 (b-isoform). This allowed us to determine wheth

• br Introduction Diacylglycerol kinase DGK is

  2020-05-22

  

  Introduction Diacylglycerol kinase (DGK) is a lipid-metabolizing enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic sc9 (PA) [[1], [2], [3], [4]]. DG and PA act as lipid second messengers in a wide variety of biological processes. Ten DGK isozymes (α, β, γ, δ, η, κ, ε, ζ, ι, a

• Moreover a ligand for fusin has recently been found the

  2020-05-22

  

  Moreover, a ligand for fusin has recently been found: the lymphocyte chemoattractant stromal-derived factor-1 (SDF-1) binds to CHO Exo1 transfected with fusin and promotes secondary messenger production (Bleul et al., 1996; Oberlin et al., 1996). A new name, CXCR-4, has been proposed for the recepto

• Another novel finding of our study was that the

  2020-05-22

  

  Another novel finding of our study was that the global 5 hmC was down-regulated and was associated with a substantial reduction of TET expression in the PE placentas compared with the controls. The decreased global 5 hmC level was consistent with the increased global 5 mC level in the preeclamptic p

• Some studies have integrated the use of cloud computing

  2020-05-22

  

  Some studies have integrated the use of cloud computing with user interfaces in the domain of our proposal (i.e. UI). In [24] the authors work with Android devices to achieve more flexibility in the user interfaces by making use of information about the environment (for example, with an ambient ligh

• Next our exploration shifted to modifications

  2020-05-22

  

  Next, our exploration shifted to modifications at the lateral chain of the benzoquinone nucleus (SAR 2). Considering that the CK2 inhibitory activity is favoured by the presence of the -Ph-4-NO2 (SAR 1), the subsequent analogues were investigated with this moiety retained. The influence of the side

• Carbamate and OP insecticides are

  2020-05-22

  

  Carbamate and OP insecticides are still among the most widely used pesticides in the world [151]. In 2012, the OP insecticides chlorpyrifos and acephate were ranked 14th and 22nd overall in estimated amounts of agricultural pesticides used in the US. The carbamate insecticide carbaryl and the OP in

• br Materials and methods br

  2020-05-22

  

  Materials and methods Results Discussion PKA and Epac are two principal effector proteins involved in cAMP signaling; they are expressed in a wide range of tissues and control diverse biological functions [10]. The existence of two cAMP effectors provides more precise regulation of cAMP sig

• Enolase is an example of a

  2020-05-22

  

  Enolase is an example of a moonlighting protein that displays multiple biological actions, including plasminogen, laminin, fibronectin, mucin and cytokeratin binding properties. It has also been described as a complement-evasion protein and as a protein capable of inducing neutrophil trap formation.

• br Acknowledgements E B was supported

  2020-05-22

  

  Acknowledgements E.B. was supported by grant 16-34-60213 mol_a_dk from the Russian Foundation for Basic Research (RFBR). R.S. and A.V. were supported by grant of the President of Russian FederationMK-4253.2018.4. The work was performed according to the Russian Government Program of Competitive Gr

• DGK type I http www apexbt

  2020-05-22

  

  DGKη1 (type II DGK) has a separated catalytic domain [10], [13], whereas the domains of DGKα, ε and ζ are not split [1], [2], [3], [4], [5]. Therefore, the structural difference may cause the distinct affinity for DG among these isozymes. Because other type II DGKs (η2, δ1, δ2 and κ) also have the s

• For this reason we hypothesized that the DHFR gene

  2020-05-22

  

  For this reason we hypothesized that the DHFR gene could be a potential candidate in clefting. Our data, obtained using a family-based association approach, evidenced an association with borderline significance for the SNP rs1677693. The variant allele A at this marker seems to reduce the risk of C

15634 records 804/1043 page Previous Next First page 上5页 801802803804805 下5页 Last page