• br Introduction Safety critical systems are defined

  2020-07-30

  

  Introduction Safety-critical systems are defined as those systems where failure could result in the loss of life or injury to people, damage to equipment or to the environment [9]. Safety standards, e.g., [41], [17], [18], [6], [38], expect appropriate safety analysis tasks to be integrated withi

• br A proposed new model of

  2020-07-29

  

  A proposed new model of interference sensitive meiotic recombination pathway In current models of meiotic recombination (Fig. 2), RAD51 and DMC1 facilitate 3′ single end invasion following DSB formation by SPO11. Using the invading 3′-end as a primer and one strand of a non-sister AGK 2 synthesis

• br Wound healing is an evolutionarily conserved pathophysiol

  2020-07-29

  

  Wound healing is an evolutionarily conserved pathophysiological paradigm of fibrogenesis. The wound healing response to injury is known to trigger functional (i.e., proliferative) and phenotypic changes throughout the skin, with involvement of multiple cell types (e.g., fibroblasts, lymphocytes, e

• Previous reports were mostly supported by chemical

  2020-07-29

  

  Previous reports were mostly supported by chemical inhibition of CDKs, but in our opinion, the observed effects are usually pharmacologically corroborated using non-selective CDK inhibitors or CDK inhibitors with unknown selectivity. The use of inhibitors with unclear selectivity might lead to misle

• Carbenoxolone disodium synthesis Notably we made the novel o

  2020-07-29

  

  Notably, we made the novel observation that expression of the growth-promoting protein survivin was greatly downregulated in the Carbenoxolone disodium synthesis with KPT-185 treatment. Furthermore, the enhanced nuclear staining of survivin in Jeko-1 tumor sections visualized by immunohistochemistr

• br Acknowledgements The study was

  2020-07-29

  

  Acknowledgements The study was supported by grant no. 501-003-11043 from the Institute of Psychiatry and Neurology in Warsaw. The authors thank Mrs. Ala Biegaj for the excellent technical assistance. Introduction In an effort to identify hIFN receptor molecules encoded by a gene(s) within hum

• br Amygdala microcircuitry and fear learning Recent

  2020-07-29

  

  Amygdala microcircuitry and fear learning Recent work has begun to dissect functional amygdala circuits that are responsible for the acquisition and expression of fear learning. Ciocchi et al. (2010) identified separable populations of EDC.HCl within the CeAL that have opposite responses to CS p

• From the results of behavioral analysis antagonizing central

  2020-07-29

  

  From the results of behavioral analysis, antagonizing central CRF1 receptors seems to be essential to suppress increase in locomotion and anxiety behaviors because Compound B did not reduce locomotion induced by central CRF challenges (Fig. 6B). Compound A decreased locomotion (Fig. 6B) and anxiety

• br Introduction Protein kinase C PKC

  2020-07-29

  

  Introduction Protein kinase C (PKC) is a prototypical class of serine/threonine kinases and influences a variety of cellular events such as cell proliferation, cell cycle, differentiation, survival, migration, and polarity [1], [2], [3]. PKC was originally identified as a cellular receptor for th

• Next zinc was reloaded via direct addition or redialysis

  2020-07-29

  

  Next, zinc was reloaded via direct addition or redialysis. The activities of CPG2 exposed to 8-, 16- and 24-ns pulses recovered to 81.1±3.9%, 70.0±4.4% and 67.9±3.6% (p=0.1258, 0.0011, 0.0002) after direct addition, and to 94.7±3.4%, 84.0±5.2% and 81.7±7.0% (p=0.0853, 0.0741, 0.0668) after redialysi

• Any web based literature search

  2020-07-28

  

  Any web-based literature search shows how the field is rapidly expanding. This is, not in small part, due to the “ENOR initiative” launched by Dr Iuliano and Dr Lizard in 2010 (). The European Network for Oxysterol Research (ENOR), via regular meetings and symposia, has helped moving the field forwa

• With respect to the duration

  2020-07-28

  

  With respect to the duration of acid-etching, few studies have shown that ceramic etching with a 5% HF during for 2–3 min is sufficient to dissolve the glassy phase [32], increasing roughness and creating a surface more favourable to bonding. Similarly, a previous study [33] showed that 10% hydroflu

• In most of the angiosperms

  2020-07-28

  

  In most of the angiosperms, sexual reproduction requires a process called double fertilization where the specialized cell division called meiosis produces haploid gametes combine to form diploid (2n) embryo. In toremifene citrate to this, apomixis, naturally occurs in at least 400 plant families (C

• While linear sequences are important they

  2020-07-28

  

  While linear sequences are important, they must be viewed with some caution. One noteworthy example is the C1 domains which have attracted some interest as they are known to bind phorbol esters and DAG (reviewed in (Das and Rahman, 2014)). In this, it was not unreasonable to suspect that one or more

• br Conflict statement br Introduction Prostate cancer

  2020-07-28

  

  Conflict statement Introduction Prostate cancer (PCa) is the second most frequently diagnosed cancer and the second leading cause of cancer death in men after lung cancer [1], [2]. The incidence and mortality rate of prostate cancer are significantly higher in developed countries especially th

15582 records 769/1039 page Previous Next First page 上5页 766767768769770 下5页 Last page