• Diabetes and atherosclerosis are paralleled by impaired woun

  2022-05-24

  

  Diabetes and atherosclerosis are paralleled by impaired wound healing and endothelial angiogenesis in the periphery, which cause severe complications and mainly occur as a result of the elevated circulating levels of glucose and free fatty acids. Yuan et al. recently showed that palmitic hydralazine

• br Conclusion The addition of cellulose to natural substrate

  2022-05-24

  

  Conclusion The addition of GI 254023X receptor to natural substrate increases the number of H-bonds which indicates an increase in the stability of the docking systems. The investigated compounds are more stable than natural substrate in docking systems, where the natural substrate has two H-bond

• Varenicline Tartrate receptor In this study we also investig

  2022-05-24

  

  In this study, we also investigated the role of GST Varenicline Tartrate receptor in relation to ASD. In univariable analyses, where the role of each GST gene (i.e., GSTM1, GSTT1, GSTP1) was individually assessed, we did not observe any significant associations between the GST genotypes and ASD. In

• Urinary hydroxypyrene OHP is a widely used biological marker

  2022-05-24

  

  Urinary 1-hydroxypyrene (1-OHP) is a widely used biological marker of exposure to PAHs and indicator for internal dose of activated PAHs (Jongeneelen, 1987, Adonis et al., 2003). PAH metabolites may be excreted either as free or as conjugated compounds. When 1-OHP is measured after treating the urin

• Recent work by Que et al

  2022-05-24

  

  Recent work by Que et al with mouse models implicates GSNOR in the cause of asthma. GSNOR is expressed in multiple cell types in the lung, including airway epithelial cells and infiltrating leukocytes. After exposure to ovalbumin, GSNOR activity increased in airway lining fluid, perhaps reflecting i

• The diversity of biological properties

  2022-05-24

  

  The Candesartan mg of biological properties and interactions of GSK-3 have been reviewed recently (, , , , ). The interactions of GSK-3 in the signaling pathways induced by nutraceuticals is covered in the review by ) in this special issue of . GSK-3 is a frequent target of many nutraceuticals such

• br Material and methods br

  2022-05-24

  

  Material and methods Results The search for proteins selectively expressed in pancreatic islet Talabostat mesylate in the Human Protein Atlas (HPA) yielded 27 hits, including well-known islet cell markers such as insulin, glucagon and pancreatic polypeptide (Table 1). The search algorithm exc

• Having shown that some of substitutions Cl

  2022-05-23

  

  Having shown that some of substitutions (Cl, CF) at the 2-position of the thiophene improved rat microsomal stability, and polar groups at the 4-position of the aryl ring had a beneficial effect on stability in both human and rat microsomes, we combined these features in a new set of analogs. Methyl

• The transporter was successfully expressed in MSCs and

  2022-05-23

  

  The transporter was successfully expressed in MSCs and HEK 293 cells. In both cell types, the expression of YFP-EAAT2 was confirmed by immunological staining and flow cytometry. The functionality of the transporter was determined by [3H]glutamate uptake assays, and the blood glutamate-grabbing activ

• br Conclusions We have shown that despite

  2022-05-23

  

  Conclusions We have shown that despite the development of severe insulin intolerance and marked alterations in whole body substrate oxidation that Gcgr−/− mice are protected against olanzapine-induced hyperglycemia. Our data provides evidence that this protective effect is likely due in large par

• Regulation of pancreatic and cell mass has been extensively

  2022-05-23

  

  Regulation of pancreatic α and β cell mass has been extensively studied and hotly debated, due to potential therapeutic implications. Early claims of Angptl8 as “betatrophin” and Angptl4 as a regulator of glucagon secretion and α cell proliferation (Yi et al., 2013, Ben-Zvi et al., 2015) have not st

• IL-2, human recombinant receptor Immunohistochemistry analys

  2022-05-23

  

  Immunohistochemistry analysis shown ghrelin and GHSR-1a immunostaining was located in the epithelial cells of IL-2, human recombinant receptor and ducts throughout the lactation, strong immunoreactive cells were detected in L30, L60 and L120 stage. The distribution of ghrelin has been shown in many

• Ghrelin contains an n octanoylation at its Ser residue Kojim

  2022-05-23

  

  Ghrelin contains an n-octanoylation at its Ser3 residue (Kojima et al., 1999). While des-acyl ghrelin is found in high concentrations in the blood, only the lipidated form is active at GHSR (Bednarek et al., 2000). We previously showed that ghrelin interacts with the membrane via its lipid modificat

• br Methods br Results br Discussion In this study

  2022-05-23

  

  Methods Results Discussion In this study, we investigated temperature effects on Vj-gating properties of two cardiac GJs. In the case of Cx45 GJs, increased temperature from 22 °C to 28 °C (or 32 °C) led to an accelerated Vj-dependent deactivation with little change in the extent of Vj-gati

• Many neutral and acidophilic galactosidases have been purifi

  2022-05-23

  

  Many neutral and acidophilic β-galactosidases have been purified from microorganisms [14], while only a few alkalophilic β-galactosidases have been reported [19]. An alkalophilic β-galactosidase, BGal_375, was obtained and researched for the characterization of its hydrolytic activity. BGal_375 show

15582 records 414/1039 page Previous Next First page 上5页 411412413414415 下5页 Last page