• has reached the significant milestone of five years in

  2018-11-12

  

  has reached the significant milestone of five years in publication and, as Editor-in-Chief, I would like to thank our publisher, Elsevier, the journal editors and our reviewers for their hard work, dedication and support in launching and establishing a new journal in the stem cell field. Most of all

• br Results br Discussion We have demonstrated that

  2018-11-12

  

  Results Discussion We have demonstrated that the hPSC-derived HBCs could be maintained on a human LN111-coated dish in an integrin α6- and β1-dependent manner (Figure 1). It is known that undifferentiated hPSCs could be maintained on a human LN511-coated dish but not on a human LN111-coated di

• For years FGF has been a requisite component

  2018-11-12

  

  For years, FGF has been a requisite component in human pluripotent stem cell media (Chen et al., 2011; Ludwig et al., 2006), and yet the mechanism by which FGF supports pluripotency was unknown. Our data show that ERK2, a downstream effector in the FGF pathway, directly phosphorylates NANOG at Ser52

• One potential explanation is autonomous

  2018-11-12

  

  One potential explanation is autonomous regulation among erythroid Doramapimod through direct contact, as they reside in clusters within the bone marrow (Neu et al., 2003). However, no secreted factors regulating erythropoiesis or signal transduction between mature erythroid cells have been identif

• br Conclusions br Acknowledgements br

  2018-11-12

  

  Conclusions: Acknowledgements Background Much of the recent attention paid to human bone marrow stromal Tenovin-6 cost (hBMSCs) is a consequence of their promise in cell-based therapy (Yi and Song, 2012). Features of BMSCs claimed that beneficial may include the capacity to home to sites o

• Molecular karyotyping identified a novel

  2018-11-12

  

  Molecular karyotyping identified a novel 2.4Mb gain on chromosome 5p14.3 and a gain on chromosome 12p11.21, which was also found in KCL040. The gain on chromosome 5p14.3 containing a single gene, CDH18 (Cadherin-18), was also present in one of two sibling cell lines, KCL032, but not in KCL034, a th

• Previous reports have described ESC based differentiation in

  2018-11-09

  

  Previous reports have described ESC-based differentiation in collagen gels to study the developmental events of vasculogenesis and angiogenesis (Feraud et al., 2001; Hermant et al., 2007). However, these were not optimized for the assessment of more fundamental aspects of vessel induction, patterni

• However there are still some challenges

  2018-11-09

  

  However, there are still some challenges that need to be addressed in order for our findings to be developed as an effective treatment for autoimmunity prevention. First, although islet function was preserved in the EV-treated mice, decreased β cell mass in association with insulitis was still obser

• In this regard an additional

  2018-11-09

  

  In this regard, an additional variable that could be critical to donor cell lineage selection is migration within the niche. Although increasing cell dose increased human cell migration in the early post-transplantation period, this effect was transient, as no changes were detected in long-term maxi

• For example some optogenetic experiments require injecting v

  2018-11-09

  

  For example, some optogenetic experiments require injecting viral material to form photosensitive proteins in target cells and subsequent illumination through the tip of the optical fiber. Doing this as a two-stage process with two different implantable devices may compromise the accuracy of the exp

• colony stimulating factor 1 receptor In this study the adsor

  2018-11-09

  

  In this study, the adsorption and colony stimulating factor 1 receptor of [RhCl5(H2O)]2− and [IrCl6]2− was investigated by using synthesized quaternary diammonium-functionalized silica-based microparticles. Both batch adsorption and column separation experiments were performed. The effect of varying

• ABT-737 Studies on the described phonology DD relationship

  2018-11-09

  

  Studies on the described phonology-DD relationship carried out in German specifically focused on the relation between vowel length discrimination and spelling (Groth et al., 2011; Landerl, 2003; Steinbrink et al., 2014). This is motivated by the following characteristics of the German language: Dura

• Descriptive analysis used medians with interquartile range I

  2018-11-09

  

  Descriptive analysis used medians with interquartile range (IQR) values. Statistical comparisons between the 3 NK groups ( Results Discussion Large cohorts for studying the correlation between NK cell deficiency and clinical events in humans are extremely rare. The study by Imai and colleagues

• Different formats have been developed

  2018-11-09

  

  Different formats have been developed for detection of resistance conferring mutations in MTB. Compared to the GeneXpert MTB/RIF assay (Boehme et al., 2010) which is limited to the detection of rifampicin resistance, line probe assays are particularly attractive due to their unmatched versatility, i

• The protein biomarkers described in this study have all

  2018-11-09

  

  The protein biomarkers described in this study have all been associated with lung cancer, and characterized previously for cancer diagnostic potential. The elevated CRP preceded lung cancer diagnosis by several years (Chaturvedi et al., 2010), and were associated with increasing lung cancer risk (Xu

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