• br Materials and methods br Acknowledgement This

  2018-11-08

  

  Materials and methods Acknowledgement This work was supported by the Korea National Institute of Health (grant number 2016-NG61002-00, 2016). Resource table Resource details E15.5 embryos were obtained from the crossing of heterozygous Sprague-Dawley (SD)-Tg(GFP)1BalRrrc rats. Rat embryos

• Mechanisms underlying CIPN include direct and indirect effec

  2018-11-08

  

  Mechanisms underlying CIPN include direct and indirect effects on sensory nerves such as damage to neuronal cell bodies in the dorsal root ganglion, alteration of the amplitude of the apoptosis or conduction velocity (Argyriou et al., 2012; Sisignano et al., 2014). Whereas CIPN may be reversible fo

• br Experimental Procedures br Author Contributions M A plann

  2018-11-08

  

  Experimental Procedures Author Contributions M.A. planned and performed the experiments and wrote the manuscript. T.N. helped in performing CTL redifferentiation experiments. S.Y. provided scientific discussion and technical support. T.Y. provided plasmids and helped in generating lentivirus v

• daminozide We observed no off target mutations in

  2018-11-08

  

  We observed no off-target mutations in our edited cell lines at eight bioinformatically predicted sites by using one-pot sgRNAs, although we cannot rule out the presence of mutations at other loci. Because optimized Cas9 mRNA and protein delivery can reduce off-target mutagenesis (Kim et al., 2014),

• br Experimental Procedures br Author Contributions br Acknow

  2018-11-07

  

  Experimental Procedures Author Contributions Acknowledgments We thank Toshio Kitamura for PLAT-A cells, and Gregg Duester and Daniel J. Donoghue for discussions. Yoav Altman, Joseph Russo, Edward Monosov, Frederick Lo, Maria Jose Martinez Lopez, Justin D. Blethrow, and Alexey Eroshkin kindl

• Go 6976 Previous reports have described ESC

  2018-11-07

  

  Previous reports have described ESC-based differentiation in collagen gels to study the developmental events of vasculogenesis and angiogenesis (Feraud et al., 2001; Hermant et al., 2007). However, these were not optimized for the assessment of more fundamental aspects of vessel induction, patternin

• br Discussion Child health research has largely been informe

  2018-11-07

  

  Discussion Child health research has largely been informed by traditional models of child development in which children progress through predictable and universal stages of development (McIntosh et al., 2013, p. 4). Within this framing, didactic teaching of knowable facts is prioritised and child

• br Introduction Thorstein Veblen s deals

  2018-11-07

  

  Introduction Thorstein Veblen\'s deals with the psychological, social, and economic issues of how institutions influence people\'s behavior from an evolutionary perspective. For Veblen, neither individuals nor institutions are taken for granted; he analyzes each from the beginning of their existe

• The consequences of the reduced exchange

  2018-11-07

  

  The consequences of the reduced exchange rate effectiveness may be observed when we make a simulation exercise based on the estimated coefficients from unrestricted model described in the column 11 of Table 3. These estimated coefficients have been chosen given that it is the SYS-GMM estimation cons

• It is clear that Lucas s insight was not new

  2018-11-07

  

  It is clear that Lucas\'s insight was not new, he even suggest its existence on the works of Frank Knight, for instance. Hicks (1936: 241) in his review of the Keynes\'s General Theory, for example, affirmed: “It is unrealistic to assume that an important change in data – say the introduction or ext

• Laboratory studies have shown that total sleep deprivation f

  2018-11-07

  

  Laboratory studies have shown that total sleep deprivation for 24–72h impairs the performance of many tasks [1,6,7]. So, it is possible that the lack of sleep may affect a basic cognitive process, such as attention, working memory or executive functions, crucial for the execution of a broad range of

• Furthermore when analysed under the light

  2018-11-07

  

  Furthermore, when analysed under the light of Foucault\'s archaeology, Veblen\'s proposal can be interpreted as a discourse “waiting to happen”. Foucault\'s archaeology of knowledge is marked by the existence of strong discontinuities between different epistemic periods in the history of knowledge.

• The original premise of this study was

  2018-11-07

  

  The original premise of this study was that the melanoma-enriched miRNAs identified in our previous study (Stark et al., 2015) would be translated directly to the expression observed in melanoma patient-derived serum. Evidence for this notion is apparent in the serially collected stage IV melanoma p

• SAG supplier We have shown that long

  2018-11-07

  

  We have shown that long-term WL/CR modulates adipocyte differentiation of ASCs in human sWAT by inducing both positive and negative regulators of the IGF-1 system at early stages of adipogenesis. Importantly, we identified DIRAS3 as novel negative regulator of adipogenesis, which slows down this pro

• In total the selected model explained se and

  2018-11-07

  

  In total, the selected model explained 60% (se=8%) and 98% (se=9%) of the phenotypic variation in MDD and SDD, respectively (Fig. 3). Strikingly, the effect of the shared couple environment contributed as much as 14% (se=7%) and 22% (se=7%) of the phenotypic variance in MDD and SDD respectively. For

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