• Pese a que se fueron debilitando los

  2018-10-25

  

  Pese CB-5083 que se fueron debilitando los procesos de autoorganización de las trabajadoras del sexo, en varios países algunos grupos han seguido reivindicado su quehacer como una cuestión laboral, y han desarrollado diversas estrategias para obtener los derechos correspondientes. El fortalecimiento

• En Suecia ha habido una serie

  2018-10-25

  

  En Suecia, ha habido una serie de evaluaciones de la ley desde su imple- mentación, aunque ninguna ha proporcionado una comparación directa de la situación antes y después de la legislación. De acuerdo con la naturaleza ideológica de la reforma, diversas encuestas y alegatos gubernamentales se enfoc

• Sin embargo desde muy temprano la

  2018-10-25

  

  Sin embargo, desde muy temprano la prensa nacional, como principal medio de difusión de noticias, había hecho su presencia entre los habitantes de este centro minero y, para estar en sintonía, se procuró crear periódicos propios ICG001 fin de dar cuenta de los sucesos particulares de la ciudad, la v

• br Hippo Yap signaling pathway in cardiac hypertrophy

  2018-10-24

  

  Hippo/Yap signaling pathway in cardiac hypertrophy and apoptosis Adult mammalian cardiomyocytes have limited proliferative capacity, and thus increased size of the adult heart with exercise or disease is caused mainly by cardiomyocyte hypertrophy. In adult heart, the functions of the Hippo pathwa

• br Results br Discussion In this study

  2018-10-24

  

  Results Discussion In this study, we examined the behavior of NPCs in response to CsA using both in vitro and in vivo models. The in vitro and in vivo studies show that CsA effectively increases the size of the NPC population. Given that SVZ-derived neurospheres are comprised of approximately

• Finally here we report the application of hiPSC CM

  2018-10-24

  

  Finally, here, we report the application of hiPSC CM to a powerful model system for the study of arrhythmia susceptibility and mechanisms based on a tachypacing system pioneered for use in an atrial tumor cell line. Rapid stimulation (in vitro tachypacing) of cultured HL-1 atrial myocytes induces ac

• Given the importance of ROCK signaling in hESC

  2018-10-24

  

  Given the importance of ROCK signaling in hESC survival, it is likely that mutations affecting the activity or expression of multiple genes in this pathway could confer a competitive advantage to mutant cells. Indeed, neither of the adapted sublines of H7 or H14 was significantly influenced at any o

• Single cell expression profiling has allowed

  2018-10-24

  

  Single-cell expression profiling has allowed researchers to test the idea that gene expression variability reflects true biological variation in cellular mRNA levels. For example, in an analysis of individual pancreatic islet cells, the transcripts of insulin genes Ins1 and Ins2 were highly correlat

• In our long term cultures of human

  2018-10-24

  

  In our long-term cultures of human iPSC CMs, the cTnI:ssTnI ratio stalled at ∼2:98, making it fetal-like with regard to the TnI isoform profile. This stalled marker of development was observed using different differentiation protocols, in multiple hiPSC lines (five hiPSC-CMs line obtained from diffe

• We provide evidence that fetal hepatic ECs also

  2018-10-24

  

  We provide evidence that fetal hepatic ECs also originate from a hepatic endoderm progenitor that expresses the vascular endothelial growth factor (VEGF) receptor KDR (VEGFR2/fetal liver kinase 1). Our previous work revealed the existence of KDR-expressing hepatic progenitors (KDR+ progenitor) in hu

• br Results br Discussion To date only one

  2018-10-24

  

  Results Discussion To date, only one genome-wide genetic screen has been performed in human ES p38 mapk inhibitor (Chia et al., 2010). The high cost associated with an siRNA library can deter investigators from utilizing this approach to decipher human stem cell biology. In this study, we sho

• While we cannot exclude the

  2018-10-24

  

  While we cannot exclude the possibility that some MYB-dependent hematopoietic progenitor palmitic acid (HPCs)/HSCs are generated during normal WT iPSC differentiation, we would expect a reduction in monocyte/macrophage production if the majority of monocytes/macrophages were derived from MYB-depend

• Induced pluripotent stem cells iPSCs are generated from vari

  2018-10-24

  

  Induced pluripotent stem 4-ethylphenyl sulfate (iPSCs) are generated from various cell types upon enforced expression of transcription factors, such as Oct4, Klf4, Sox2, and c-Myc (Takahashi et al., 2007). T cells could also convert into iPSCs (T-iPSCs), retaining rearranged TCR genes from the orig

• Yet at the same time the extent of human variability

  2018-10-24

  

  Yet at the same time the extent of human variability, of which we are only beginning to take the full measure, poses an important practical problem for the field of iPSC-based modeling. Given background genetic differences between individuals, the key question is which experimental designs and degre

• br Introduction Acute myeloid leukemia AML comprises a

  2018-10-24

  

  Introduction Acute myeloid leukemia (AML) comprises a biologically and genetically heterogeneous group of disorders characterized by the rapid expansion of immature myeloid blasts in bone marrow (BM) (Bene et al., 2015; Grimwade et al., 2016). Disease heterogeneity is well documented and patients

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