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adenosine deaminase br Conclusion This study demonstrated th
2018-10-29
Conclusion This study demonstrated that intragastrical administration of 100mg/kgbwd CGMP could significantly reduce the number of ACF in rats with DMH-induced colorectal cancer, indicating that CGMP plays certain preventive roles in colorectal carcinogenesis. From the epigenetics point of view,
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Research in rodents suggests that NPCs are interesting candi
2018-10-29
Research in rodents suggests that NPCs are interesting candidates for cell-based therapy of various neurodegenerative diseases. For example, transplantation of NPCs can improve cognition in a mouse model of Alzheimer\'s disease (Blurton-Jones et al., 2009), induce remyelination in a mouse model of m
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In the present study we isolated defined populations of ASC
2018-10-29
In the present study, we isolated defined populations of ASC from human abdominal subcutaneous fat tissue derived from 4 different women. The immunophenotype and the in vitro differentiation capacity of these ion channels were analyzed after expansion in medium with low concentrations of FBS until
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Based on the ability to
2018-10-29
Based on the ability to derive hESC lines with an extra copy of a particular chromosome, the different trisomies can be divided in two groups. One group comprises trisomies for those chromosomes found to be present in blastomeres by PGS, but unlikely to survive as trisomic ESC lines. This is the cas
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To the best of our knowledge
2018-10-29
To the best of our knowledge, only three metabolites, L-threonine, butyrate, and vitamin C, have been identified so far that act as epigenetic modulators of ESC self-renewal and/or somatic cell reprogramming (Mali et al., 2010; Shyh-Chang et al., 2013; Wang et al., 2009). Interestingly, L-threonine,
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br Experimental Procedures br Author Contributions br Introd
2018-10-26
Experimental Procedures Author Contributions Introduction Frontotemporal dementia (FTD) refers to a group of neurodegenerative diseases caused by focal but progressive neuronal loss, astrogliosis, and spongiosis in the frontal and temporal cortices associated with abnormal intracellular acc
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In this article we searched for genes
2018-10-26
In this article, we searched for genes that are induced by KLF4 in a dose-dependent manner and identified Tcl1 as its direct target. KLF4 induces Tcl1 transcription during reprogramming via direct binding to its enhancer and promoter regions, concurrently changing repressive histone marks into activ
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We speculated that MEKi might decrease
2018-10-26
We speculated that MEKi might decrease DNA methylation levels through the downregulation of the DNMT3 family. MEKi significantly diminished global DNA methylation levels and, surprisingly, was sufficient to induce high 5hmC levels. Because the TET family of dioxygenases that catalyze the conversion
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br The connection between the yield point of
2018-10-26
The connection between the yield point of a material and the surface tension actin inhibitor of its particles As follows from Fig. 1, the surface tension coefficient rapidly decreases with a decrease in the particle size R/δ of the material, for particles with sizes less than 20δ (about 20nm). I
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Continuous and discrete radiation frequency wavelength
2018-10-26
Continuous and discrete radiation frequency (wavelength) tuning can be achieved in waveguide CO2 lasers by placing a diffraction grating in a special optical bruton\'s tyrosine kinase [4,5] and by using optical cavities coupling out the radiation to a zero or first diffraction order. The wavelength
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br Reduction of the patient s radiation
2018-10-26
Reduction of the patient\'s radiation load The main reason why background radiation appears in the radiation room during proton therapy of the eye is that the majority of the protons are absorbed by the system generating the treatment beam, by the equipment and by the walls of the radiation room.
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We found that men had higher
2018-10-26
We found that men had higher levels of AL scores than women across every age category, a novel finding among US Hispanics/Latinos of diverse backgrounds. In analyses of specific AL components, metabolic markers were generally higher in men and inflammatory markers were higher in women. Sex differenc
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A pragmatic trial program highlights the tension
2018-10-26
A pragmatic trial program highlights the tension between two perspectives of clinical research. In the traditional view, all clinical research puts patients at risk and therefore they must be protected through informed consent. In the pragmatic triallist’s view, the fact that both treatment arms rep
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br Materials and methods br Results and discussion br
2018-10-26
Materials and methods Results and discussion Conclusions The centre composite design of response surface methodology was successfully used in optimising the reaction conditions for biodiesel production from waste vegetable oil in the presence of Rupatadine Fumarate Supplier heterogeneous ca
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Using the above equation Eq the
2018-10-26
Using the above equation (Eq. (2)), the surface concentration in our case was found to be 0.23×10−8mol/cm2. The diffusion coefficient (D) value of the redox species from the electrolyte to L/IL/ITO electrode was calculated using the Randles–Sevcik equation given by [33]where Ip is the peak current o
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