• br Conflict of interest br Acknowledgements

  2021-04-06

  

  Conflict of interest Acknowledgements The authors are grateful to laboratory technician Kristina Andersson for expert technical assistance. The authors acknowledge the Swedish Research Council (Grant no. 6834), Region Skåne and Faculty of Medicine, Lund University, for financial support. In

• Protein deubiquitination is becoming increasingly instrument

  2021-04-06

  

  Protein deubiquitination is becoming increasingly instrumental in understanding the complexities of the Ub system. Adding to this complexity is the discovery of bacterial effectors with DUB activity that have structurally adapted themselves to interfere with the eukaryotic Ub system (Pruneda et al.,

• Multiple sequence alignment of the proteins in the

  2021-04-06

  

  Multiple sequence alignment of the proteins in the DGAT1 sub-family shows that there are about 41 conserved amino lpl receptor residues distributed over seven sequence motifs [74]. Unlike DGAT2, a large number of DGAT1 residues, including a majority of the conserved residues, are found in a loop on

• br Material and methods br Results br Discussion In the

  2021-04-06

  

  Material and methods Results Discussion In the present study, twenty strains of Y. enterocolitica were analyzed for their inhibitory potential on cysteine proteases. Five of these strains belonged to bioserotype 4/O:3, which is distinguished for its pathogenicity towards humans. The rest of

• Experiments on the rat model of E

  2021-04-06

  

  Experiments on the rat model of E. coli pyelonephritis, performed to investigate the relationship between the acute inflammatory processes and the permanent kidney damage (Brooks et al., 1974), have demonstrated a positive correlation between the degree of free radical-mediated renal injury and the

• These contrasting results observed with intra BNST combined

  2021-04-06

  

  These contrasting results observed with intra-BNST combined injections of NOC-9 and CP 376395 on freezing (in the novel arena) versus anxiety-related behavior (in the EPM) suggest that CRF neurotransmission within this forebrain limbic site could be mainly involved in the modulation of more subtle a

• br Materials and methods br Results br Discussion Intra BNST

  2021-04-06

  

  Materials and methods Results Discussion Intra-BNST injections of NOC-9 (at all doses) were able to produce freezing and anxiogenic-like effects. Freezing was observed immediately after the NO donor injection and lasted about 2–3min (data not shown). When exposed to the EPM 5min after intra

• 3-Deazaneplanocin receptor br Conclusions Enzyme can be deli

  2021-04-06

  

  Conclusions Enzyme can be delivered to the tumour by using humanised or fully human 3-Deazaneplanocin receptor or even loaded into synthetic nanospheres produced from silica [64] or liposomally entrapped [65]. For any future ADEPT developments, a number of basic points need to be considered. As i

• Leukotrienes themselves are implicated in

  2021-04-06

  

  Leukotrienes themselves are implicated in the development of gastrointestinal ulcers, asthmas, and different inflammatory processes [18], [19]. It is noteworthy that COX isozymes and LOX share the same substrate arachidonic acid; therefore, inhibition of prostaglandins production by cyclooxygenase p

• Recent advances in microarray and next generation sequencing

  2021-04-02

  

  Recent advances in microarray [32] and next-generation sequencing [33] based technologies have led to tremendous increases in information about the molecular mechanisms that are responsible for malignant transformation of rare and poorly understood soft tissue sarcomas. However, data interpretation

• br Materials and methods br Results br Discussion Here we

  2021-04-02

  

  Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic 143 93 induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter status epilepti

• is one of the few parasites that can

  2021-04-02

  

  is one of the few parasites that can be encysted and excysted and we tested the localization and role of HA-tagged gEno in both differentiations, using a recently developed integrated vector that introduces a C-terminal triple HA tag under the selection marker puromycin . The localization of HA-ta

• Contrary to the downregulation of S PR

  2021-04-02

  

  Contrary to the downregulation of S1PR family GPCRs, CLL cells have increased mRNA expression of the lysophosphatidic rq 1 synthesis (LPA) family receptors LPAR1, LPAR3 and LPAR4 compared to normal B cells [47]. Increased LPAR1 mRNA has been shown to be associated with more aggressive disease [47]

• The two most important biological machineries controlling pr

  2021-04-02

  

  The two most important biological machineries controlling proteostasis, PQC, and degradation are autophagy and the ubiquitin-proteasome system (UPS) (). Autophagy is a lysosome-dependent, tightly regulated catabolic process that degrades unwanted cell organelles and cytoplasmic constituents in lysos

• Except for S adenosylmethionine SAM

  2021-04-02

  

  Except for S-adenosylmethionine (SAM, Fig. 1), sources of endogenous DNA alkylation are not well defined. Other possible sources include nitroso compounds related to the well known mutagen methylnitrosourea which are generated in vitro by nitrosation of cellular amines including amino acids, protein

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