• 822 br HIF Signaling in AA Therapy Resistance

  2023-04-06

  

  HIF-α Signaling in AA Therapy Resistance An important result emerging from Phase 3 clinical trials testing AA therapies is improvement of progression-free survival (PFS) that is not accompanied by enhanced overall survival (OS) [26]. This dichotomy has been attributed to mechanisms of acquired re

• However although in vitro studies in

  2023-04-06

  

  However, although in vitro studies in heterologous systems have provided very important indications of potential novel pharmacology, the studies with endogenous receptors in native tissues are essential to provide evidence for GPCR heteromerization in vivo and to confirm its physiological relevance.

• Two patients developed diffuse mesangio proliferative glomer

  2023-04-06

  

  Two patients developed diffuse mesangio-proliferative glomerulonephritis (DMPG) postoperatively, presenting as nephrotic syndrome and benign haematuria, respectively. DMPG has been reported in an adult patient with thymomatous MG following thymectomy [35], and various types of glomerulonephritis hav

• br Author contributions br Competing interests br Transparen

  2023-04-06

  

  Author contributions Competing interests Transparency document Acknowledgments This research was funded by a TOP ZonMW grant (40-00812-98-10054) to R.O.E., a DFG grant (KR4391/1-1) and IZKF Erlangen grant (J36) to A.K. and supported in part by Centro de Investigación Biomédica en Red de

• Exposure to cisplatin with ATR inhibitor resulted

  2023-04-06

  

  Exposure to cisplatin with ATR inhibitor resulted in an increase in cisplatin-DNA adducts, especially in cells with ATM deficiency. This finding indicates that suppressing ATR-Chk1 signaling with VE-822 enhances cisplatin activity by enabling the drug to form DNA adducts. Therefore, VE-822 may incre

• Plant tissues were thought to be natural sources

  2023-04-03

  

  Plant tissues were thought to be natural sources containing different types of antioxidant compounds (tocopherols, ascorbic acid, carotenoids, and phenolic compounds). As a general classification, antioxidants were grouped as vitamins (ascorbic acid, tocopherols), carotenoids (condensed tannins, xan

• br Introduction Alzheimer s disease

  2023-03-30

  

  Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different sorafenib tosylate areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper and Karra

• br Introduction Alzheimer s disease

  2023-03-30

  

  Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different sorafenib tosylate areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper and Karra

• The inflammatory cytokine IL is an

  2023-03-28

  

  The inflammatory cytokine IL-6 is an additional factor that has been hypothesized to contribute to epinephrine-mediated repression of drug detoxifying proteins such as CYP3A4 (Aninat et al., 2008). Indeed, this CYP is well-known to be repressed by IL-6 (Dickmann et al., 2011) and epinephrine has pre

• We now present a series of findings obtained

  2023-03-28

  

  We now present a series of findings obtained in heterologous expression systems, brain slices, and living animals that suggest that any interaction between mGlu7 and α1-adrenergic receptors exists, is specific, and is physiologically and behaviourally relevant. Materials and methods Norepinephri

• To identify the kinase s mediating H S

  2023-03-27

  

  To identify the kinase(s) mediating H3.3S31 phosphorylation, we devised a 96-well-plate-compatible immunostaining assay, with Cinchonidine sale specific for H3.3S31ph, and utilized it to screen both a Qiagen siRNA library covering 720 human kinases and a kinase inhibitor library (Selleck) containin

• Many ruthenium complexes were tested as potential anticancer

  2023-03-27

  

  Many ruthenium complexes were tested as potential anticancer agents and two complexes, namely NAMI-A (trans-[imH] [RuCl4(dmso-S)(im)]; im, imidazole) and KP1019 (trans-[indH][RuCl4(ind)2]; ind, indazole) have successfully entered clinical trials [27], [28]. NAMI-A is selectively active against metas

• However most of these SBVS studies were focused on

  2023-03-27

  

  However, most of these SBVS studies were focused on the target(s) for which crystal structures were available or have a similar template in PDB for comparative modeling. Besides, these were limited to SBVS only which relies on the rigid binding pocket, therefore, it may result in high false positive

• Our previous studies and others have identified

  2023-03-27

  

  Our previous studies and others have identified that the inhalational anesthetic isoflurane induces neuronal apoptosis via [Ca2+]i overload through the opening of synaptic voltage-dependent calcium channels (VDCCs) and the excessive Ca2+ release from the endoplasmic reticulum (Zhao et al., 2011; Zha

• In the MT SGL two regularization parameters need to be

  2023-03-22

  

  In the MT-SGL, two regularization parameters need to be specified: λ1 and λ2. Using recent results on norm regularization (Banerjee et al., 2014), it is possible to express both parameters via a single parameter as follows: and (Meier et al., 2008, Banerjee et al., 2014), where and are computed as:

15696 records 314/1047 page Previous Next First page 上5页 311312313314315 下5页 Last page